Home (S,E)-Methyl-2-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol — “Diol Compound” CAS Number 142569-70-8 Category Intermediate Final Application Montelukast Sodium Known industry-wide simply as the “montelukast diol,” this chiral quinoline-containing intermediate already carries the drug’s chlorostyryl-quinoline and hydroxypropyl-phenyl fragments joined together. It is converted to the corresponding mesylate and coupled with the mercaptoacetic-acid fragment to complete Montelukast Sodium.   Your name […]

Home 5-Cyanoindole CAS Number 15861-24-2 Category Intermediate Final Application Vilazodone Molecular Formula C9H6N2 Molecular Weight 142.16 5-Cyanoindole is the indole-core starting material for Vilazodone, an antidepressant combining SSRI and 5-HT1A partial agonist activity. The cyano group and indole nitrogen are functionalized in later steps to build vilazodone’s benzofuran-carboxamide and piperazinylbutyl side chains. Your name Your […]

Home 5-Nitro-3-(trifluoromethyl) Picolinonitrile CAS Number 573762-57-9 Category Intermediate Final Application Apalutamide Molecular Formula C7H2F3N3O2 Molecular Weight 217.11 An early-stage nitro-substituted picolinonitrile intermediate in the Apalutamide synthetic route; the nitro group is subsequently reduced to the corresponding amine and then converted to the isothiocyanate used in the API’s final coupling step. Your name Your email Your […]

Home 5-Isothiocyanato-3-(trifluoromethyl) Picolinonitrile CAS Number 951735-87-0 Category Intermediate Final Application Apalutamide Molecular Formula C8H2F3N3S Molecular Weight 229.19 This isothiocyanate-functionalized picolinonitrile is the key coupling partner used in the final cyclization step of Apalutamide manufacture, reacting with the cyanocyclobutylamino-benzamide fragment to form the drug’s thiohydantoin core. . Your name Your email Your message (optional)

Home 4-(1-Cyanocyclobutylamino)-2-Fluoro-N-Methylbenzamide CAS Number 915087-26-2 Category Intermediate Final Application Apalutamide Molecular Formula C13H14FN3O Molecular Weight 247.27 A cyanocyclobutyl-substituted fluorobenzamide intermediate central to Apalutamide synthesis, formed by coupling the cyanocyclobutylamine fragment to the fluorobenzamide core before cyclization with the pyridyl-isothiocyanate fragment to complete the API. Note: this same CAS number also appears in the Campaign-based Products […]

Home 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile CAS Number 573762-62-6 Category Intermediate Final Application Apalutamide Molecular Formula C7H4F3N3 Molecular Weight 187.12 A trifluoromethyl-pyridine intermediate used in the multi-step synthesis of Apalutamide, a nonsteroidal androgen receptor inhibitor used in prostate cancer treatment. The aminopyridine-carbonitrile core is later converted to the isothiocyanate used to build apalutamide’s thiohydantoin core. . Your name Your […]

Home Corey Lactone Diol CAS Number 32233-40-2 Category Intermediate Final Application Prostaglandins Molecular Formula C8H12O4 Molecular Weight 172.18 The Corey lactone diol is a classical, versatile bicyclic lactone building block used as the common starting synthon for a wide family of prostaglandin-analogue APIs including latanoprost, bimatoprost, travoprost, and carboprost  onto which the characteristic prostaglandin side […]

Home   ATS-8 — (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate </h1 > CAS Number 125971-94-0 Category Intermediate Final Application Atorvastatin ATS-8 is a chiral acetonide-protected dioxane intermediate that supplies the defined (4R,6R) stereochemistry required for Atorvastatin’s pharmacologically active diol side chain. As a late-stage chiral intermediate, its enantiomeric purity is one of the most tightly controlled quality attributes in atorvastatin […]

Home 1-(Hydroxymethyl)cyclopropane acetonitrile CAS Number 152922-71-9 Category Intermediate Final Application Montelukast Sodium Molecular Formula C6H9NO Molecular Weight 111.14 A cyclopropane-nitrile building block used upstream in Montelukast Sodium manufacturing. Its hydroxymethyl and nitrile groups are carried through subsequent steps to construct the cyclopropylacetic-acid/thiol side chain characteristic of montelukast’s structure. Your name Your email Your message (optional)

Home   2-[1-(Mercaptomethyl)cyclopropyl] Acetic Acid </h1 > CAS Number 162515-68-6 Category Intermediate Final Application Montelukast Sodium Molecular Formula C6H10O2S Molecular Weight 146.20 A key thiol-bearing cyclopropane intermediate used in the synthesis of Montelukast Sodium. Its free mercapto (–SH) group performs the critical thioether-forming conjugation step late in the montelukast route, and its purity directly affects […]