| CAS Number | 951735-87-0 |
|---|---|
| Category | Intermediate |
| Final Application | Apalutamide | Molecular Formula | C8H2F3N3S | Molecular Weight | 229.19 |
This isothiocyanate-functionalized picolinonitrile is the key coupling partner used in the final cyclization step of Apalutamide manufacture, reacting with the cyanocyclobutylamino-benzamide fragment to form the drug’s thiohydantoin core.
.